Product Information
83020-1-PBS targets FDFT1 in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | FDFT1 fusion protein Ag3743 Predict reactive species |
Full Name | farnesyl-diphosphate farnesyltransferase 1 |
Calculated Molecular Weight | 417 aa, 48 kDa |
Observed Molecular Weight | 48 kDa |
GenBank Accession Number | BC029641 |
Gene Symbol | FDFT1 |
Gene ID (NCBI) | 2222 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P37268 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
SQS (Squalene synthase), also known as Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is a gene that encodes the membrane-associated enzyme squalene synthase, which is the first specific enzyme in cholesterol biosynthesis. FDFT1 is highly expressed in liver, lung, prostate, breast, ovary, bladder, cervix, thyroid, and esophageal cancers, while in colorectal, colon, testicular, uterine, pancreas, and kidney tumors, its expression is downregulated (PMID: 35093030). FDFT1 is a key downstream target of the fasting response and may be involved in CRC cell glucose metabolism (PMID: 32313017).