Product Information
66639-1-PBS targets FANCL in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | FANCL fusion protein Ag6192 Predict reactive species |
Full Name | Fanconi anemia, complementation group L |
Calculated Molecular Weight | 43 kDa |
Observed Molecular Weight | 41-43 kDa |
GenBank Accession Number | BC054517 |
Gene Symbol | FANCL |
Gene ID (NCBI) | 55120 |
RRID | AB_2881998 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9NW38 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Fanconi anemia (FA) is a hereditary bone marrow failure syndrome associated with developmental defects and cancer predisposition. The FA nuclear core complex consists of FANCA, B, C, E, F, G, L, and M. FANCL is a RING-type E3 ubiquitin ligase that monoubiquitinates FANCD2 and FANCI, a key functional role facilitated by other members of the nuclear core complex (PMID: 23783032). FANCL plays an important role in the repair of cisplatin-induced DNA damage (PMID: 26385482) and participates directly in support of stem cell function (PMID: 23783032). FANCL can be detected as 40-43 kDa (full-length) and ~28 kDa.