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FANCL Monoclonal antibody, PBS Only

FANCL Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 66639-1-PBS
Clone No.6E2B6

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

WB, IF/ICC, Indirect ELISA

FAAP43, FANCL, Fanconi anemia group L protein, PHF9, POG

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

66639-1-PBS targets FANCL in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen FANCL fusion protein Ag6192 Predict reactive species
Full Name Fanconi anemia, complementation group L
Calculated Molecular Weight 43 kDa
Observed Molecular Weight 41-43 kDa
GenBank Accession NumberBC054517
Gene Symbol FANCL
Gene ID (NCBI) 55120
RRIDAB_2881998
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9NW38
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Fanconi anemia (FA) is a hereditary bone marrow failure syndrome associated with developmental defects and cancer predisposition. The FA nuclear core complex consists of FANCA, B, C, E, F, G, L, and M. FANCL is a RING-type E3 ubiquitin ligase that monoubiquitinates FANCD2 and FANCI, a key functional role facilitated by other members of the nuclear core complex (PMID: 23783032). FANCL plays an important role in the repair of cisplatin-induced DNA damage (PMID: 26385482) and participates directly in support of stem cell function (PMID: 23783032). FANCL can be detected as 40-43 kDa (full-length) and ~28 kDa.

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