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CNTN1 Monoclonal antibody, PBS Only

CNTN1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig, rabbit

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C1D4

Cat no : 68252-1-PBS

Synonyms

CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CNTN1 Monoclonal antibody (68252-1-Ig)

    WB analysis using 68252-1-Ig (same clone as 68252-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68252-1-Ig (CNTN1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68252-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CNTN1 Monoclonal antibody (68252-1-Ig)

    WB analysis using 68252-1-Ig (same clone as 68252-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68252-1-Ig (CNTN1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68252-1-PBS in a different storage buffer formulation.

Product Information

68252-1-PBS targets CNTN1 in WB, Indirect ELISA applications and shows reactivity with Human, pig, rabbit samples.

Tested Reactivity Human, pig, rabbit
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen CNTN1 fusion protein Ag5030
Full Name contactin 1
Calculated Molecular Weight 1018 aa, 113 kDa
Observed Molecular Weight130-135 kDa
GenBank Accession NumberBC036569
Gene Symbol CNTN1
Gene ID (NCBI) 1272
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).