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CLUH Recombinant antibody, PBS Only

CLUH Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241640C11

Cat no : 84321-4-PBS

Synonyms

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using CLUH Recombinant antibody (84321-4-RR)

    IF Staining of HeLa using 84321-4-RR (same clone as 84321-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CLUH antibody (84321-4-RR, Clone: 241640C11 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84321-4-PBS in a different storage buffer formulation.

Product Information

The immunogen of 84321-4-PBS is CLUH Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CLUH fusion protein Ag34275
Full Name KIAA0664
GenBank Accession NumberBC156940
Gene Symbol CLUH
Gene ID (NCBI) 23277
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)