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Anti-Human TWEAKR/CD266 Rabbit Recombinant Antibody, PBS Only

TWEAKR/CD266 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240991C5

Cat no : 98125-1-PBS

Synonyms

CD266, TNFRSF12A, TweakR, FGF inducible 14, DR3LG

Validation Data Gallery

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  • Flow cytometry (FC) experiment of HT-1080 cells using Anti-Human TWEAKR/CD266 Rabbit Recombinant Antibod (98125-1-RR)

    FC experiment of HT-1080 using 98125-1-RR (same clone as 98125-1-PBS)

    1x10^6 HT-1080 cells were surface stained with 0.25 ug Anti-Human TWEAKR Rabbit Recombinant Antibody (98125-1-RR, Clone: 240991C5) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98125-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98125-1-RR

    Affinity and Kinetic Characterization of 98125-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98125-1-RR against Human CD266 were performed. The affinity constant is 0.508 nM.

Product Information

The immunogen of 98125-1-PBS is TWEAKR/CD266 Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TWEAKR/CD266 fusion protein Ag13823
Full Name tumor necrosis factor receptor superfamily, member 12A
Calculated Molecular Weight 129 aa, 14 kDa
GenBank Accession NumberBC002718
Gene Symbol TWEAKR
Gene ID (NCBI) 51330
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TWEAKR (also known as CD266, FN14, TNFRSF12A) is a member of the TNF receptor superfamily which is activated by its ligand, the cytokine TWEAK (TNFSF12). TWEAKR is the smallest member of the TNFR superfamily. TweakR was first described as an FGF-inducible gene that played a role in fibroblast adhesion and migration. Subsequently, the induction of TweakR expression by other growth factors and/or upon tissue injury was observed in multiple cell types, including hepatocytes, endothelial cells, adipocytes, and cardiomyocytes. (PMID: 23073510, PMID: 24409185)