Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of U266 using 98215-1-RR (same clone as 98215-1-PBS)

  1x10^6 U266 cells (left) or HEK-293T (right) were surface stained with 0.25 ug Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody (98215-1-RR, Clone: 241731A11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98215-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98215-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98215-1-RR against Human BCMA/TNFRSF17 were performed. The affinity constant is 0.20 nM.

BCMA/TNFRSF17 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98215-1-PBS

Clone No.241731A11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

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Product Information

98215-1-PBS targets BCMA/TNFRSF17 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: tumor necrosis factor receptor superfamily, member 17
• Calculated Molecular Weight: 184 aa, 20 kDa
• GenBank Accession Number: BC058291
• Gene Symbol: TNFRSF17
• Gene ID (NCBI): 608
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q02223
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).