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CoraLite® Plus 488-conjugated BACE1 Polyclonal antibody

BACE1 Polyclonal Antibody for IF

Host / Isotype

Rabbit / IgG


human, mouse, zebrafish, rat




CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-12807


Asp 2, ASP2, Aspartyl protease 2, BACE, BACE1, Beta secretase 1, FLJ90568, HSPC104, KIAA1149, Memapsin 2

Tested Applications

Positive IF detected inNeuro-2a cells

Recommended dilution

Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-12807 targets BACE1 in IF applications and shows reactivity with human, mouse, zebrafish, rat samples.

Tested Reactivity human, mouse, zebrafish, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen BACE1 fusion protein Ag3559
Full Name beta-site APP-cleaving enzyme 1
Calculated Molecular Weight 501 aa, 56 kDa
Observed Molecular Weight 70-75 kDa, 42-56 kDa
GenBank Accession NumberBC036084
Gene Symbol BACE1
Gene ID (NCBI) 23621
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

beta-secretase, encoded by BACE1(beta-stie amyloid beta A4 precursor protein-cleavage enzyem1) gene, is a neuron-specific membrane-associated protease that participate in the two step proteolytic processing of the APP. Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has a high expression in the brain and pancreas. This protein has 6 isoforms produced by alternative splicing. BACE1 can be detected with different molecular weight: 42-56kD (prozymogen and isoforms), 65-75 (glycosylated forms) and 160kDa (dimer) (PMID:22741101; 21795680).


Product Specific Protocols
IF protocol for CL Plus 488 BACE1 antibody CL488-12807Download protocol
Standard Protocols
Click here to view our Standard Protocols