Anti-Human Siglec-7/CD328 Rabbit Recombinant Antibody
Siglec-7/CD328 Uni-rAbTM Recombinant Antibody for FC
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
FC
Conjugate
Unconjugated
CloneNo.
241525H1
Cat no : 98183-1-RR
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | human peripheral blood leukocytes |
Recommended dilution
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
98183-1-RR targets Siglec-7/CD328 in FC applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Recombinant protein |
Full Name | sialic acid binding Ig-like lectin 7 |
Calculated Molecular Weight | 51kDa |
GenBank Accession Number | NM_014385.4 |
Gene Symbol | Siglec-7 |
Gene ID (NCBI) | 27036 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
Storage Conditions | Store at 2 - 8°C. Stable for one year after shipment. |
Background Information
Sialic acid binding Ig-like lectin 7 (Siglec-7), also known as CD328 or p75/AIRM-1, is a member of the Siglec family of glycan-recognition proteins. Siglec-7 is a type-I transmembrane protein consisting of three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs (PMID: 32322597; 10567377). It is mainly expressed on immune cells, with low levels on granulocytes, intermediate levels on monocytes, and relatively high levels on a major subset of natural killer cells and a minor subset of CD8+ T cells (PMID: 10567377). Siglec-7 is an inhibitory receptor that negatively regulates the function of NK cells and modulates the immune response through the interaction of sialic acid-containing ligands (PMID: 27312286).
Protocols
Product Specific Protocols | |
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FC protocol for Siglec-7/CD328 antibody 98183-1-RR | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |