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CNNM4 Recombinant antibody, PBS Only (Capture)

CNNM4 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

240873E9

Cat no : 83824-4-PBS

Synonyms

KIAA1592, Cyclin-M4, cyclin M4, Ancient conserved domain-containing protein 4, ACDP4

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CNNM4 Recombinant antibody (83824-4-RR)

    WB analysis using 83824-4-RR (same clone as 83824-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83824-4-RR (CNNM4 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83824-4-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP00802-3

    Cytometric bead array standard curve of MP00802-3

    Cytometric bead array standard curve of MP00802-3, CNNM4 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83824-4-PBS. Detection antibody: 83824-2-PBS. Standard: Ag5121. Range: 0.313-40 ng/mL.

  • Affinity and Kinetic Characterization of 83824-4-RR

    Affinity and Kinetic Characterization of 83824-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83824-4-RR against Human CNNM4 were performed. The affinity constant is below 1 pM.

Product Information

83824-4-PBS targets CNNM4 as part of a matched antibody pair:

MP00802-3: 83824-4-PBS capture and 83824-2-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CNNM4 fusion protein Ag5121
Full Name cyclin M4
Calculated Molecular Weight 87 kDa
Observed Molecular Weight 90-100 kDa
GenBank Accession NumberBC063295
Gene Symbol CNNM4
Gene ID (NCBI) 26504
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Ancient conserved domain-containing protein 4/cyclin M4 (CNNM4), a membrane protein that stimulates Mg2+ efflux, binds phosphatase of regenerating liver (PRL), which is frequently overexpressed in malignant human cancers (PMID: 25347473). CNNM4 is predominant in the brain, bone marrow, immune system, and especially abundant in the intestinal tract. CNNM4 localizes at the basolateral membrane of the intestinal epithelia and mediates transcellular Mg2+ transport (PMID: 27006114).