• Phare
  • Validé par KD/KO

Anticorps Polyclonal de lapin anti-OSMR

OSMR Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, singe et plus (1)

Applications

WB, IF, IHC, ELISA

Conjugaison

Non conjugué

N° de cat : 10982-1-AP

Synonymes

IL 31 receptor subunit beta, IL 31R beta, IL 31R subunit beta, IL 31RB, oncostatin M receptor, OSMR, OSMR β, OSMRB, OSMRβ



Applications testées

Résultats positifs en WBcellules HeLa, cellules A375, cellules HEK-293T, cellules HepG2, cellules Raji

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

10982-1-AP cible OSMR dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain, singe

Réactivité Humain, singe
Réactivité citéeHumain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène OSMR Protéine recombinante Ag1426
Nom complet oncostatin M receptor
Masse moléculaire calculée 110 kDa
Poids moléculaire observé 110 kDa
Numéro d’acquisition GenBankBC010943
Symbole du gène OSMR
Identification du gène (NCBI) 9180
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Oncostatin M (OSM) is a member of interleukin-6 family cytokines that modulates proliferation and differentiation in numerous cells (PMID: 22982441). OSM signals via a receptor complex comprising gp130 and the OSMR (also refered to as OSMRβ) (PMID: 8999038). OSMR is a single-pass membrane protein that belongs to the type I cytokine receptor family. OSMR mRNA is expressed at relatively high levels in all neural cells and fibroblast, epithelial, and various tumor cell lines (PMID: 8999038). It has also been shown that OSMR associates with IL31RA to form the heterodimeric IL31 receptor (PMID: 15184896). A 70 kDa soluble form can be detected by western blot (PMID: 17028186).

Protocole

Product Specific Protocols
WB protocol for OSMR antibody 10982-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
human,mouseWB

Cell Stem Cell

Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.

Authors - Kubin Thomas T
mouse,humanIF

Sci Adv

Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.

Authors - Melissa Valussi
  • KO Validated
humanIHC

Cell Rep

Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

Authors - Yiheng Mao
IF

Br J Dermatol

CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption.

Authors - V Patra
humanWB

Aging (Albany NY)

Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.

Authors - Jing-Yuan Cao
mouseWB

Stem Cell Res Ther

Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.

Authors - Jie Zhou
  • KD Validated