IL-17A Polyklonaler Antikörper

IL-17A Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF, FC, IHC, ELISA, Cell treatment

Konjugation

Unkonjugiert

Kat-Nr. : 13082-1-AP

Synonyme

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A



Geprüfte Anwendungen

Erfolgreiche Detektion in IHChumanes Kolonkarzinomgewebe, humanes Kolongewebe, humanes Magenkrebsgewebe, humanes Zervixkarzinomgewebe
Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

AnwendungVerdünnung
Immunhistochemie (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

13082-1-AP bindet in WB, IF, FC, IHC, ELISA, Cell treatment IL-17A und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IL-17A fusion protein Ag3733
Vollständiger Name interleukin 17A
Berechnetes Molekulargewicht 155 aa, 18 kDa
GenBank-ZugangsnummerBC067505
Gene symbol IL-17A
Gene ID (NCBI) 3605
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody got 32-35 kDa band in western blot, maybe due to homodimer formation and differential glycosylations.

Protokolle

Produktspezifische Protokolle
IHC protocol for IL-17A antibody 13082-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
humanIF

J Autoimmun

IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.

Authors - Sakthi Rajendran
WB

J Med Chem

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.

Authors - Ji-An Chen
IHC

J Invest Dermatol

Reduced Il17a expression distinguishes a Ly6c(lo)MHCII(hi) macrophage population promoting wound healing.

Authors - Rodero Mathieu P MP
IF

Arch Oral Biol

Age-related changes of CD4+ T cell migration and cytokine expression in germ-free and SPF mice periodontium.

Authors - Koichiro Irie
WB

Cell Physiol Biochem

Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.

Authors - Yang Yang
WB

J Cell Mol Med

Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.

Authors - Yahui Zhou