CD11B/Integrin Alpha M Polyklonaler Antikörper

CD11B/Integrin Alpha M Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

21

Kat-Nr. : 20991-1-AP

Synonyme

CD11B, CR 3 alpha chain, CR3A, Integrin alpha M, ITGAM, MAC 1, MAC1A, MO1A, Neutrophil adherence receptor, SLEB6

---

Galerie der Validierungsdaten

• 

  IHC staining of human tonsillitis using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human tonsillitis using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human liver using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human liver using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 40x lens).

---

Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 15 publications below
• IHC: See 6 publications below
• IF: See 2 publications below

Produktinformation

20991-1-AP bindet in WB, IHC, IF, ELISA CD11B/Integrin Alpha M und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: integrin, alpha M (complement component 3 receptor 3 subunit)
• Berechnetes Molekulargewicht: 93 kDa
• Beobachtetes Molekulargewicht: 110-170 kDa
• GenBank-Zugangsnummer: NM_000632
• Gene symbol: ITGAM
• Gene ID (NCBI): 3684
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

Publikationen

Species	Application	Title
	IHC	J Nanobiotechnology; Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells; Authors - Hua‑Zhen Xu
human	IHC	Cancer Lett; Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.; Authors - Xiong Zhang
human	WB	Cancer Immunol Immunother; Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.; Authors - Pei Yang
	IF	J Nanobiotechnology; Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.; Authors - Shen-Jun Yuan
	IHC	Neuropharmacology; Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide.; Authors - Liqing Zhang
	WB,IHC	Mol Neurobiol; Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration.; Authors - Weisong Duan

Verwandte Produkte

CD68 Polyclonal antibody

25747-1-AP

CD68 Monoclonal antibody

66231-1-Ig

CD11c/Integrin Alpha X Monoclonal antibody

60258-1-Ig

CD11c/Integrin Alpha X Polyclonal antibody

17342-1-AP

ICAM-1 Monoclonal antibody

60299-1-Ig

ICAM-1 Polyclonal antibody

10831-1-AP

Fibrinogen Gamma Chain Monoclonal antibody

66158-1-Ig