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Animal-free Recombinant Human Pleiotrophin-PTN0 Publications

Catalog number: HZ-1278

HEK293 expressed Endotoxin-free Animal-component free

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Format: Lyophilized

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Technical Specifications

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Pleiotrophin-PTN purity

The protein was resolved by SDS-polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. R represents reducing conditions and NR represents non-reducing conditions.

GeneID:
5764
Species:
Human
Expression:
HEK293
Activity:
N/A
Purity:
>95%
Molecular Mass:
18 kDa, monomer, non-glycosylated
Formulation
1x PBS, See Certificate of Analysis for details
Species Reactivity:
human, rat

Stability and Reconstitution

Stability and Storage:
Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.


Reconstitution:
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Product Description:

Animal-free Recombinant Human Pleiotrophin is expressed in Human 293 cells as a secreted unglycosylated monomer. PTN is a member of a family of heparin-binding proteins that share sequence, structural, and functional similarity. Other members of this family include midkine (MK), and chicken retinoic acid- induced heparin-binding protein (RI-HB), an avian homologue of MK. The expression of all these cytokines is restricted and highly regulated during development.



Background:

Pleiotrophin is a secreted growth factor that induces neurite outgrowth being mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) inducing MAPK pathway activation, as an important step in the anti-apoptotic signaling of PTN and cell proliferation (PMID:1768439; 1733956; 11278720)



Synonyms:
Pleiotrophin, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1) Heparin-binding growth factor8(HBGF8), Heparin-binding growth factor 8(HBGF 8), Osteoblast-Specific Factor1 (OSF1), Osteoblast-Specific Factor 1 (OSF 1)



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