• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Activin A protein

Activity

0.5-3.5 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1138

Synonyms

Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A



Technical Specifications

GeneID 3624
Species Human
Expression HEK293
Activity 0.5-3.5 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP08476
Molecular Mass 25 kDa, homodimer, non-glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Activin A, a member of the TGF-β superfamily, was named for its ability to activate FSH secretion from the anterior pituitary gland (PMID 16885530). Three activins have been identified in human tissues: activin A, activin B, and activinAB, of which activin A is the most studied. Activin A has various functions in regulating cell differentiation, proliferation, apoptosis and carcinogenesis (PMID 8200957). Xeno-free Recombinant Human Activin A is expressed from human 293 cells as disulfide linked homodimers with molecular mass of 25 kDa.

Synonyms

Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A

Publications

SpeciesTitle
human

Protein Cell

Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells.

Authors - Chen Ling
human

Tissue Eng Part C Methods

Essential components for ex vivo proliferation of mesenchymal stromal cells.

Authors - NatalieFekete
human

Cell Rep

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.

Authors - Pengze Yan
human

STAR Protoc

Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells.

Authors - Pooja Hor
mouse

Birth Defects Res B Dev Reprod Toxicol

Lost in translation: The search for an in vitro screen for spermatogenic toxicity.

Authors - Robert EChapin
human

Eur J Obstet Gynecol Reprod Biol

Effects of gremlin-2 on the transition of primordial follicles during early folliculogenesis in the human ovary.

Authors - YukiIkeda