- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human Activin A protein
Cat no : HZ-1138
Synonyms
Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A
Validation Data Gallery
Technical Specifications
GeneID | 3624 |
Species | Human |
Expression | HEK293 |
Activity | 0.5-3.5 ng/mL EC50 |
Purity | >95% |
Endotoxin | <1 EU/μg |
Accession Number | P08476 |
Molecular Mass | 25 kDa, homodimer, non-glycosylated |
Formulation | 1x PBS, See Certificate of Analysis for details |
Species Reactivity | human,mouse |
Stability and Reconstitution
Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
---|---|---|---|
Lyophilized | -20°C to -80°C | Until Expiry Date | |
Lyophilized | Room Temperature | 2 weeks | |
Reconstituted as per CofA | -20°C to -80°C | 6 months | |
Reconstituted as per CofA | 4°C | 1 week | |
Avoid repeated freeze-thaw cycles. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
Activin A, a member of the TGF-β superfamily, was named for its ability to activate FSH secretion from the anterior pituitary gland (PMID 16885530). Three activins have been identified in human tissues: activin A, activin B, and activinAB, of which activin A is the most studied. Activin A has various functions in regulating cell differentiation, proliferation, apoptosis and carcinogenesis (PMID 8200957). Xeno-free Recombinant Human Activin A is expressed from human 293 cells as disulfide linked homodimers with molecular mass of 25 kDa.
Synonyms
Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A
Publications
Species | Title |
---|---|
Protein Cell Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. | |
Tissue Eng Part C Methods Essential components for ex vivo proliferation of mesenchymal stromal cells. | |
STAR Protoc Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. | |
Birth Defects Res B Dev Reprod Toxicol Lost in translation: The search for an in vitro screen for spermatogenic toxicity. | |
Eur J Obstet Gynecol Reprod Biol Effects of gremlin-2 on the transition of primordial follicles during early folliculogenesis in the human ovary. |