• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-21 protein


0.25-1.25 ng/mL

Species Reactivity




Cat no : HZ-1319


Interleukin 21, Interleukin-21, Interleukin-21 isoform, Za11, CVID11

Technical Specifications

GeneID 59067
Species Human
Expression HEK293
Activity(Primary) 0.25-1.25 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ9HBE4
Molecular Mass 18 kDa reduced, 17 kDa non-reduced, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.


IL-21 is a type I, 4-α-helix bundle cytokine primarily produced by CD4+ T cells and NK cells. It is a strong activator of proliferation and antibody production in B cells but does signal to numerous other immune cells as well. Elevated IL-21 signaling can promote several autoimmune diseases including type I diabetes, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). However, it has also been shown to have potent antitumoral activity, making it a promising candidate for immunotherapy and as an adjuvant material in CAR-T cell therapy (PMID: 22235123, 26966515, 27577879).


Interleukin 21, Interleukin-21, Interleukin-21 isoform, Za11, CVID11




Human microglia maturation is underpinned by specific gene regulatory networks

Authors - Claudia Z Han