ZMPSTE24 Recombinant antibody, PBS Only

ZMPSTE24 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241288C11

Cat no : 84547-1-PBS

Synonyms

FACE-1, FACE1, FACE 1, EC:3.4.24.84, CAAX prenyl protease 1 homolog

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Validation Data Gallery

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  WB analysis using 84547-1-RR (same clone as 84547-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84547-1-RR (ZMPSTE24 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84547-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84547-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84547-1-RR against Human ZMPSTE24 were performed. The affinity constant is 1.87 nM.

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Product Information

The immunogen of 84547-1-PBS is ZMPSTE24 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: ZMPSTE24 fusion protein Ag33613
• Full Name: zinc metallopeptidase (STE24 homolog, S. cerevisiae)
• Calculated Molecular Weight: 475 aa, 55 kDa
• Observed Molecular Weight: 60 kDa
• GenBank Accession Number: BC037283
• Gene Symbol: ZMPSTE24
• Gene ID (NCBI): 10269
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

ZMPSTE24(CAAX prenyl protease 1 homolog) gene encodes a zinc metalloproteinase involved in the processing of farnesylated proteins(PubMed: 10373325). The significance of ZMPSTE24 in human disease stems from its role as an enzyme necessary for the correct processing and maturation of lamin A ,an intermediate filament component of the nuclear envelope (PubMed: 16297189).