Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of bEnd.3 using 98251-1-RR (same clone as 98251-1-PBS)

  1x10^6 bEnd.3 cells (left) or C2C12 (right) were surface stained with 0.25 ug Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody (98251-1-RR, Clone: 241953D4) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98251-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98251-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98251-1-RR against Mouse VE-cadherin/CD144 were performed. The affinity constant is 1.65 nM.

VE-cadherin/CD144 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98251-1-PBS

Clone No.241953D4

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

VE-cadherin, VE Cad, Cdh5, Cd144, cadherin 5

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Product Information

98251-1-PBS targets VE-cadherin/CD144 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: cadherin 5
• Calculated Molecular Weight: 88kDa
• GenBank Accession Number: NM_009868.4
• Gene Symbol: Cdh5
• Gene ID (NCBI): 12562
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P55284
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609).