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- KD/KO Validated
USP1 Monoclonal antibody, PBS Only
USP1 Monoclonal Antibody for WB, IHC, ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human, rat
Applications
WB, IHC, ELISA
Conjugate
Unconjugated
CloneNo.
1C10H6
Cat no : 66069-1-PBS
Synonyms
Validation Data Gallery
Product Information
66069-1-PBS targets USP1 in WB, IHC, ELISA applications and shows reactivity with human, rat samples.
Tested Reactivity | human, rat |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | USP1 fusion protein Ag5904 |
Full Name | ubiquitin specific peptidase 1 |
Calculated Molecular Weight | 88 kDa |
Observed Molecular Weight | 100 kDa |
GenBank Accession Number | BC050525 |
Gene Symbol | USP1 |
Gene ID (NCBI) | 7398 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
USP1(Ubiquitin carboxyl-terminal hydrolase 1) is a negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.It is Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA.This protein, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases(PMID:9806842). The USP1 enzyme can undergo autocleavage, resulting in a 100 kDa N-terminal fragment and a 14 kDa C-terminal fragment(PMID:18082604).