Anti-Human TSLP Rabbit Recombinant Antibody, PBS Only

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  FC experiment of HUVEC using 98247-1-RR (same clone as 98247-1-PBS)

  1x10^6 untreated or IL-4, TNF-α and BFA-treated HUVEC cells were intracellularly stained with 0.25 ug Anti-Human TSLP Rabbit RecAb (98247-1-RR, Clone: 241821B2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98247-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98247-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98247-1-RR against Human TSLP were performed. The affinity constant is 2.85 nM.

TSLP {ptg:Brand} Recombinant Antibody for FC (Intra)

Cat No. 98247-1-PBS

Clone No.241821B2

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

Synonyms

Thymic stromal lymphopoietin, 241821B2

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Product Information

98247-1-PBS targets TSLP in FC (Intra) applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: thymic stromal lymphopoietin
• Calculated Molecular Weight: 18 kDa
• GenBank Accession Number: NM_033035.5
• Gene Symbol: TSLP
• Gene ID (NCBI): 85480
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q969D9-1
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain, it mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Another isoform of this protein may act as an antimicrobial peptide in the oral cavity and on the skin (PMID: 24850429).