TPX2 Monoclonal antibody, PBS Only
TPX2 Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, mouse, rat
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2E10C1
Cat no : 68712-1-PBS
Synonyms
Validation Data Gallery
Product Information
68712-1-PBS targets TPX2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Reactivity | Human, mouse, rat |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | TPX2 fusion protein Ag33683 |
Full Name | TPX2, microtubule-associated, homolog (Xenopus laevis) |
Calculated Molecular Weight | 747 aa, 86 kDa |
Observed Molecular Weight | 98 kDa |
GenBank Accession Number | BC020207 |
Gene Symbol | TPX2 |
Gene ID (NCBI) | 22974 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TPX2, also known as DIL2, p10, is a microtubule organization- and cell cycle-associated protein. In the early stage of mitosis, TPX2 is released in a RanGTP-dependent manner and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. Furthermore, during interphase, TPX2 is involved in DNA damage response by regulation of γ-H2AX signals(PMID: 25914189). Aberrant expression of TPX2 leads to improper spindle assembly and chromosomal instability. Overexpressed in cancers, TPX2 is being established as the marker for the diagnosis and prognosis of malignancies(PMID: 24556998).