TPR Recombinant antibody, PBS Only

TPR Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 83177-5-PBS
Clone No.230413A2

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, ELISA

Nucleoprotein TPR, 230413A2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

83177-5-PBS targets TPR in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide Predict reactive species
Full Name translocated promoter region (to activated MET oncogene)
Calculated Molecular Weight 267 kDa
Observed Molecular Weight~270 kDa
GenBank Accession NumberNM_003292
Gene Symbol TPR
Gene ID (NCBI) 7175
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP12270
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Nucleoporin TPR was originally identified as the oncogenic activator of the met, raf, and trk protooncogenes. TPR is a large 270 kDa protein with a bipartite structure consisting of a ~1600-residue a-helical coiled-coil N-terminal domain and a highly acidic non-coiled ~800 amino acid carboxy terminus (PMID: 22253824). TPR is localized exclusively to intranuclear filaments associated with the nucleoplasmic side of the NPC, by directly binding to Nup153 (PMID: 12802065).

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