Product Information
83177-5-PBS targets TPR in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Peptide Predict reactive species |
Full Name | translocated promoter region (to activated MET oncogene) |
Calculated Molecular Weight | 267 kDa |
Observed Molecular Weight | ~270 kDa |
GenBank Accession Number | NM_003292 |
Gene Symbol | TPR |
Gene ID (NCBI) | 7175 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | P12270 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Nucleoporin TPR was originally identified as the oncogenic activator of the met, raf, and trk protooncogenes. TPR is a large 270 kDa protein with a bipartite structure consisting of a ~1600-residue a-helical coiled-coil N-terminal domain and a highly acidic non-coiled ~800 amino acid carboxy terminus (PMID: 22253824). TPR is localized exclusively to intranuclear filaments associated with the nucleoplasmic side of the NPC, by directly binding to Nup153 (PMID: 12802065).