TERF1 Monoclonal antibody, PBS Only

TERF1 Monoclonal Antibody for Indirect ELISA, WB

Host / Isotype

Mouse / IgG1

Reactivity

rat, mouse, human

Applications

Indirect ELISA, WB

Conjugate

Unconjugated

CloneNo.

1D10G4

Cat no : 67592-1-PBS

Synonyms

Telomeric repeat-binding factor 1, t TRF1, PIN2, NIMA-interacting protein 2, hTRF1 AS

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Validation Data Gallery

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  WB analysis of K-562 using 67592-1-Ig (same clone as 67592-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 67592-1-Ig (TERF1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67592-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 67592-1-Ig (same clone as 67592-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 67592-1-Ig (TERF1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67592-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Jurkat using 67592-1-Ig (same clone as 67592-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 67592-1-Ig (TERF1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67592-1-PBS in a different storage buffer formulation.

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Product Information

67592-1-PBS targets TERF1 in Indirect ELISA, WB applications and shows reactivity with rat, mouse, human samples.

• Tested Reactivity: rat, mouse, human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: TERF1 fusion protein Ag12540
• Full Name: telomeric repeat binding factor (NIMA-interacting) 1
• Calculated Molecular Weight: 439 aa, 50 kDa
• Observed Molecular Weight: 48-50 kDa
• GenBank Accession Number: BC029378
• Gene Symbol: TERF1
• Gene ID (NCBI): 7013
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Telomeres are nucleoprotein complexes located at chromosome ends that consist of tandem arrays of TTAGGG repeats bound to specific proteins. Telomeres protect chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. TERF1 (telomeric repeat-binding factor 1) binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. It's one component of the shelterin complex, which involved in the regulation of telomere length and protection.