TCTN3 Polyclonal antibody, PBS Only

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  WB analysis using 16085-1-AP (same clone as 16085-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16085-1-AP (TCTN3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IP experiment of Hela cells using 16085-1-AP (same clone as 16085-1-PBS)

  IP result of anti-TCTN3 (16085-1-AP for IP and Detection). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

TCTN3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 16085-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

TECT3, TCTN 3, PSEC0041, OFD4, JBTS18

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Product Information

16085-1-PBS targets TCTN3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TCTN3 fusion protein Ag9084
• Full Name: tectonic family member 3
• Calculated Molecular Weight: 607 aa, 66 kDa
• Observed Molecular Weight: 66 kDa
• GenBank Accession Number: BC009494
• Gene Symbol: TCTN3
• Gene ID (NCBI): 26123
• RRID: AB_10638442
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6NUS6
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

TCTN3 (tectonic-3 or TECT3) is a type I membrane protein that belongs to the tectonic family, which consists of TCTN1, TCTN2 and TCTN3. Studies in mice suggest that tectonic may be involved in Hedgehog (Hh) signaling, and essential for ciliogenesis. Tectonic is component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. TCTN3 is necessary for transduction of the sonic hedgehog (SHH) signaling pathway. Orofaciodigital syndromes (OFDSs) consist of a group of heterogeneous disorders characterized by abnormalities in the oral cavity, face, and digits and associated phenotypic abnormalities. Recently, TCTN3 mutations are found as the cause of an extreme form of OFD associated with bone dysplasia, tibial defect, cystic kidneys, and brain anomalies.