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Product Information
84089-4-PBS targets TCF1/TCF7 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | TCF1/TCF7 fusion protein Ag5792 Predict reactive species |
| Full Name | transcription factor 7 (T-cell specific, HMG-box) |
| Calculated Molecular Weight | 42 kDa |
| Observed Molecular Weight | 58 kDa |
| GenBank Accession Number | BC048769 |
| Gene Symbol | TCF1/TCF7 |
| Gene ID (NCBI) | 6932 |
| ENSEMBL Gene ID | ENSG00000081059 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P36402 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
TCF7, also known as TCF1, belongs to the TCF/LEF family. TCF7 is part of the Wnt signaling pathway and plays an important role in the differentiation and self-renewal of memory T cells. It has been found that TCF7 is necessary to revive T cells in response to PD-1 blockade against viral infection or cancer. TCF7 is mainly expressed in T-cells and is also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. TCF7 has 16 isoforms with the molecular mass of 28-54 kDa (PMID: 34044317).
