TCF1/TCF7 Recombinant antibody, PBS Only

TCF1/TCF7 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241154D2

Cat no : 84089-4-PBS

Synonyms

TCF7, TCF-1, TCF1, TCF 7, TCF 1

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Validation Data Gallery

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  WB analysis using 84089-4-RR (same clone as 84089-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84089-4-RR (TCF7 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84089-4-PBS in a different storage buffer formulation.

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Product Information

The immunogen of 84089-4-PBS is TCF1/TCF7 Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TCF1/TCF7 fusion protein Ag5792
• Full Name: transcription factor 7 (T-cell specific, HMG-box)
• Calculated Molecular Weight: 42 kDa
• Observed Molecular Weight: 58 kDa
• GenBank Accession Number: BC048769
• Gene Symbol: TCF7
• Gene ID (NCBI): 6932
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

TCF7, also known as TCF1, belongs to the TCF/LEF family. TCF7 is part of the Wnt signaling pathway and plays an important role in the differentiation and self-renewal of memory T cells. It has been found that TCF7 is necessary to revive T cells in response to PD-1 blockade against viral infection or cancer. TCF7 is mainly expressed in T-cells and is also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. TCF7 has 16 isoforms with the molecular mass of 28-54 kDa (PMID: 34044317).