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Serotonin transporter Recombinant antibody, PBS Only

Serotonin transporter Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242252B9

Cat no : 84844-3-PBS

Synonyms

SLC6A4, HTT, hSERT, 5HTT, 5 HTTLPR

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Serotonin transporter Recombinant antibody (84844-3-RR)

    WB analysis using 84844-3-RR (same clone as 84844-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84844-3-RR (Serotonin transporter antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84844-3-PBS in a different storage buffer formulation.

Product Information

84844-3-PBS targets Serotonin transporter in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide
Full Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Calculated Molecular Weight 70 kDa
Observed Molecular Weight70 kDa
GenBank Accession NumberNM_001045
Gene Symbol Serotonin transporter
Gene ID (NCBI) 6532
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Serotonin transporter (SERT; SLC6A4) belongs to the sodium- and chloride-dependent monoamine transporter family. SERT is a membrane transporter that terminates the neurotransmission of serotonin, a monoaminergic neurotransmitter, through its reuptake. The SERT uptake mechanism acquires energy for active transport via ATP hydrolysis or movement against electrochemical gradients. As an oligomeric N-glycan, SERT contains disulfide bonds between cysteine residues on the second extracellular domain. Post-translational modifications regulate the uptake kinetics and membrane trafficking of SERT, partly by regulating the proper folding and assembly of SERT in a host-dependent manner (PMID: 30394319).