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SOCS3 Monoclonal antibody, PBS Only
SOCS3 Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse
Applications
WB, IHC, IF-P, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1G2B12
Cat no : 66797-1-PBS
Synonyms
Validation Data Gallery
Product Information
66797-1-PBS targets SOCS3 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, mouse samples.
Tested Reactivity | Human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | SOCS3 fusion protein Ag5386 |
Full Name | suppressor of cytokine signaling 3 |
Calculated Molecular Weight | 25 kDa |
Observed Molecular Weight | 25 kDa |
GenBank Accession Number | BC060858 |
Gene Symbol | SOCS3 |
Gene ID (NCBI) | 9021 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Suppressor of cytokine signaling 3 (SOCS3) is a member of SOCS family that these proteins induced to attenuate cytokine signal transduction in response to signals from a diverse range of cytokines and growth factors. SOCS3 is a negative regulatory protein that inhibits signaling induced by IL-6 via preventing JAK mediated activation of STAT3. However SOCS3 can positively regulate the ERK-MAPK pathway, inhibit the NF-kB pathway (PMID:26429311,25035930). In addition, SOCS3 brings a great impact on immune responses by inhibiting signaling stimulus, such as LPS, type I and type II IFNs, and IL-12. SOCS3 is widely expressed in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney (PMID: 22961088). Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer (PMID:26429311).