Anti-Human SIRP beta 1/CD172b Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human peripheral blood leukocytes using 98267-1-RR (same clone as 98267-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human SIRP beta 1/CD172b Rabbit Recombinant Antibody (98267-1-RR, Clone: 242115C10) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98267-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98267-1-RR (same clone as 98267-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human SIRP beta 1/CD172b Rabbit Recombinant Antibody (98267-1-RR, Clone: 242115C10) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98267-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98267-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98267-1-RR against Human SIRP beta 1/CD172b were performed. The affinity constant is 22.8 pM.

SIRP beta 1/CD172b {ptg:Brand} Recombinant Antibody for FC

Cat No. 98267-1-PBS

Clone No.242115C10

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

SIRP BETA 1, SIRPB1, Signal-regulatory protein beta-1 isoform 3, Signal-regulatory protein beta-1, CD172b

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Product Information

98267-1-PBS targets SIRP beta 1/CD172b in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: signal-regulatory protein beta 1
• Calculated Molecular Weight: 43kDa
• GenBank Accession Number: NM_006065.5
• Gene Symbol: SIRPB1
• Gene ID (NCBI): 10326
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: O00241-1
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

SIRP beta 1, also known as CD172b, is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRP family members are cell surface signaling receptors differentially expressed in leukocytes and the central nervous system. SIRP beta 1 interacts with TYROBP/DAP12, a protein-bearing immunoreceptor tyrosine-based activation motif. SIRP beta 1 also participates in the recruitment of tyrosine kinase SYK.