Product Information
67352-1-PBS targets SEC63 in WB, IF/ICC, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | SEC63 fusion protein Ag5783 Predict reactive species |
Full Name | SEC63 homolog (S. cerevisiae) |
Calculated Molecular Weight | 88 kDa |
Observed Molecular Weight | 90 kDa |
GenBank Accession Number | BC047221 |
Gene Symbol | SEC63 |
Gene ID (NCBI) | 11231 |
RRID | AB_2882608 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q9UGP8 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
SEC63 is a integral ER membrane protein. SEC63 and SEC62 form a dimeric complex and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER. Mutations in the gene encoding SEC63 cause polycystic liver disease in humans. The intact SEC63 protein is usually detected around 83-90 kDa, while smaller cleavage products can be observed by autophagy proteolysis (PMID: 25052096)