SEC63 Monoclonal antibody, PBS Only
SEC63 Monoclonal Antibody for WB, IF/ICC, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
WB, IF/ICC, ELISA
Conjugate
Unconjugated
CloneNo.
1C10E1
Cat no : 67352-1-PBS
Synonyms
Validation Data Gallery
Product Information
67352-1-PBS targets SEC63 in WB, IF/ICC, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | SEC63 fusion protein Ag5783 |
Full Name | SEC63 homolog (S. cerevisiae) |
Calculated Molecular Weight | 88 kDa |
Observed Molecular Weight | 90 kDa |
GenBank Accession Number | BC047221 |
Gene Symbol | SEC63 |
Gene ID (NCBI) | 11231 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
SEC63 is a integral ER membrane protein. SEC63 and SEC62 form a dimeric complex and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER. Mutations in the gene encoding SEC63 cause polycystic liver disease in humans. The intact SEC63 protein is usually detected around 83-90 kDa, while smaller cleavage products can be observed by autophagy proteolysis (PMID: 25052096)