SCN5A Monoclonal antibody, PBS Only

SCN5A Monoclonal Antibody for Indirect ELISA, IHC, WB

Host / Isotype

Mouse / IgG1

Reactivity

rabbit, rat, mouse, human

Applications

Indirect ELISA, IHC, WB

Conjugate

Unconjugated

CloneNo.

1C2B3

Cat no : 68273-1-PBS

Synonyms

Nav1.5, HH1, CMPD2, CMD1E, CDCD2



Product Information

68273-1-PBS targets SCN5A in Indirect ELISA, IHC, WB applications and shows reactivity with rabbit, rat, mouse, human samples.

Tested Reactivity rabbit, rat, mouse, human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen SCN5A fusion protein Ag19275
Full Name sodium channel, voltage-gated, type V, alpha subunit
Calculated Molecular Weight 2016 aa, 227 kDa
Observed Molecular Weight227 kDa
GenBank Accession NumberBC140813
Gene Symbol SCN5A
Gene ID (NCBI) 6331
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Voltage-gated sodium channels are responsible for initiation and propagation of action potentials in the membranes of neurons and most electrically excitable cells (PMID: 10798388). These channels are composed of a large alpha subunit that forms the ion conduction pore and auxiliary beta subunits (PMID: 11486343). The alpha subunits form a gene family with at least 10 members. Nav1.5, encoded by the SCN5A gene in humans, is a pore forming alpha subunit of voltage-gated sodium channels. Nav1.5 is the principal Na+ channel isoform expressed in cardiomyocytes. Mutations in SCN5A gene have been linked to many cardiac electrical disorders, including the congenital and acquired long QT syndrome, Brugada syndrome, conduction slowing, sick sinus syndrome, atrial fibrillation, and dilated cardiomyopathy (PMID: 23123192).