ROR2 Monoclonal antibody, PBS Only

ROR2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A12C5

Cat no : 67906-1-PBS

Synonyms

BDB, BDB1, NTRKR2, ROR2

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Validation Data Gallery

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  WB analysis using 67906-1-Ig (same clone as 67906-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Alpha Tubulin Monoclonal antibody (HRP-66031) as loading control. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 67906-1-Ig (same clone as 67906-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

• 

  WB analysis of NIH/3T3 using 67906-1-Ig (same clone as 67906-1-PBS)

  NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

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Product Information

67906-1-PBS targets ROR2 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

• Tested Reactivity: Human, Mouse, Rat
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: ROR2 fusion protein Ag31197
• Full Name: receptor tyrosine kinase-like orphan receptor 2
• Calculated Molecular Weight: 943 aa, 105 kDa
• Observed Molecular Weight: 105 kDa
• GenBank Accession Number: BC130522
• Gene Symbol: ROR2
• Gene ID (NCBI): 4920
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Tyrosine-protein kinase transmembrane receptor ROR2 belongs to the ROR family of receptor tyrosine kinases (RTKs) (PMID: 12815588). ROR2 is a developmentally regulated protein that has significant expression and roles in a wide variety of tissues during early embryonic development. It was established that ROR2 plays a key role in skeletal and neural organogenesis, as well as in midgut development in the mouse, but then becomes repressed in adult tissues. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PMID: 25614331). Mutations in the ROR2 gene are associated with autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B (PMID: 12815588).