Product Information
84058-5-PBS targets RNF40 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | RNF40 fusion protein Ag8047 Predict reactive species |
| Full Name | ring finger protein 40 |
| Calculated Molecular Weight | 114 kDa |
| Observed Molecular Weight | 135 kDa |
| GenBank Accession Number | BC006133 |
| Gene Symbol | RNF40 |
| Gene ID (NCBI) | 9810 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | O75150 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double-strand break (DSB). The DDR involves extensive dynamics of protein post-translational modifications, most notably phosphorylation and ubiquitylation. A recently identified novel component of the DDR pathway - histone H2B monoubiquitylation - exemplifies this principle. Monoubiquitination of histone H2B is a dynamic post-translational histone modification associated with transcriptional elongation and the DNA damage response [PMID:22021426]. In mammalian cells, H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40 [PMID:22031019,21827756].
