RBP4 Recombinant antibody, PBS Only
RBP4 Uni-rAbTM Recombinant Antibody for Indirect ELISA, WB
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
Indirect ELISA, WB
Conjugate
Unconjugated
CloneNo.
6O13
Cat no : 82934-1-PBS
Synonyms
Validation Data Gallery
Product Information
82934-1-PBS targets RBP4 in Indirect ELISA, WB applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | RBP4 fusion protein Ag2448 |
Full Name | retinol binding protein 4, plasma |
Calculated Molecular Weight | 201 aa, 23 kDa |
Observed Molecular Weight | 23 kDa |
GenBank Accession Number | BC020633 |
Gene Symbol | RBP4 |
Gene ID (NCBI) | 5950 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
RBP4 (retinol-binding protein 4) is a carrier protein that transports vitamin A (retinol) from the liver to the peripheral tissues. Synthesized primarily by hepatocytes and adipocytes as a 21 kDa non-glycosylated protein, RBP4 is secreted into the circulation as a retinol-RBP4 complex. In plasma the RBP4-retinol complex is bound to transthyretin (TRR), which prevents prevent kidney filtration. Two truncated forms of RBP4, RBP4-L (truncated at Leu-183) and RBP4-LL (truncated at Leu-182 and Leu-183), exist by proteolytic process. RBP4-L and RBP4-LL, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. Urinary RBP4 has been reported as marker for glomerular disease. RBP4 also was identified as an adipokine that elevated in some INS-resistant states. Measurement of serum RBP4 could be used to assess the risk of INS resistance, type 2 diabetes, obesity, and cardiovascular disease. (18752671, 16034410)