Phospho-ULK1 (Ser556) Recombinant antibody, PBS Only
Phospho-ULK1 (Ser556) Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2F5
Cat no : 80218-1-PBS
Synonyms
Validation Data Gallery
Product Information
80218-1-PBS targets Phospho-ULK1 (Ser556) in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.
Tested Reactivity | Human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Peptide |
Full Name | unc-51-like kinase 1 (C. elegans) |
Observed Molecular Weight | 140 kDa |
GenBank Accession Number | NM_003565 |
Gene Symbol | ULK1 |
Gene ID (NCBI) | 8408 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. ULK1 is phosphorylated on serine 638 and 758 sites by mTOR in nutrient-rich conditions, inhibiting ULK1 activation by disrupting its binding to AMPK. Upon glucose starvation, dissociation of mTOR from ULK1 and phosphorylation by AMPK leads to the activation of ULK1 activity. The S556 site of ULK1 is one of the major AMPK-dependent phosphorylation sites. (PMID: 30517873, PMID: 21258367)