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Phospho-TAU (Ser202/Thr205) Recombinant antibody, PBS Only

Phospho-TAU (Ser202/Thr205) Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, Mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4A6

Cat no : 82568-1-PBS

Synonyms

DDPAC, FLJ31424, FTDP 17, MAPT, MAPTL, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, Phospho-TAU (Ser202/Thr205), PPND, TAU

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using Phospho-TAU (Ser202/Thr205) Recombinant antibody (82568-1-RR)

    WB analysis of mouse brain using 82568-1-RR (same clone as 82568-1-PBS)

    Phosphatase inhibitor treated and λ phosphatase treated mouse brain tissue were subjected to SDS PAGE followed by western blot with 82568-1-RR (Phospho-TAU (Ser202/Thr205) antibody) at dilution of 1:10000 incubated at room temperature for 1 hours. The membrane was stripped and re-blotted with Beta Actin antibody as loading control. This data was developed using the same antibody clone with 82568-1-PBS in a different storage buffer formulation.

Product Information

82568-1-PBS targets Phospho-TAU (Ser202/Thr205) in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide
Full Name microtubule-associated protein tau
Calculated Molecular Weight 37-46, 79-81 kDa
Observed Molecular Weight45-55 kDa
GenBank Accession NumberBC000558
Gene Symbol TAU
Gene ID (NCBI) 4137
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Tau (tubulin-associated unit) is a microtubule-associated protein (also known as MAPT), expressed mainly in neurons of the central nervous system. Its primary function is to modulate microtubule dynamics for maintaining axonal cytoskeleton. The Tau protein has six isoforms produced from a single gene through alternative RNA splicing. Isoforms differ in number of inserts at the N-terminal half and the number of repeats at the C-terminal half (3 repeat-3R; 4 repeat-4R). Tau is hyperphosphorylated during aging and in age-related neurodegenerative diseases such as Alzheimer's disease (AD) and fronto-temporal dementia. Hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles (NFT) in the neurons and glia cells, which is one of the hallmarks of AD.