Phospho-Cardiac Troponin I (Ser23/24) Recombinant antibody, PBS Only

Phospho-Cardiac Troponin I (Ser23/24) Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85002-1-PBS
Clone No.241982B1

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

cTnI, Cardiac troponin I, TNNI3, 241982B1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

85002-1-PBS targets Phospho-Cardiac Troponin I (Ser23/24) in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide Predict reactive species
Full Name troponin I type 3 (cardiac)
Calculated Molecular Weight 210 aa, 24 kDa
Observed Molecular Weight26 kDa
GenBank Accession NumberBC096165
Gene Symbol Cardiac Troponin I
Gene ID (NCBI) 7137
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP19429
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Cardiac Troponin I (cTnI) is produced by cardiac muscle. To date, most investigative effort in phosphorylation mediated regulation of cTnI function has focused on the actions of PKA and PKC. Evidence from studies in a variety of systems, ranging from reconstituted myofilament proteins to cultured myocytes or transgenic animals with heterologous expression of modified cTnI proteins, indicates that PKA-mediated functional effects (eg, decreased myofilament Ca2 sensitivity) are mediated principally through the phosphorylation of Ser22/23 (equivalent to Ser23/24, including the initiating Met, in the rodent sequence) within the unique N-terminal extension of cTnI. (PMID: 15514163)

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