Product Information
27794-1-PBS targets Periostin in IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Periostin fusion protein Ag27145 Predict reactive species |
Full Name | periostin, osteoblast specific factor |
GenBank Accession Number | BC106710 |
Gene Symbol | Periostin |
Gene ID (NCBI) | 10631 |
RRID | AB_2880975 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q15063 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Periostin (POSTN, PN), originally named as osteoblast-specific factor 2 (OSF-2), is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues, and has a role in bone, tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types, including lung, ovary, breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour, and it is required to allow cancer stem cell maintenance.