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PRKCB Monoclonal antibody, PBS Only

PRKCB Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat, pig, rabbit

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4B7A1

Cat no : 68620-1-PBS

Synonyms

PKC beta, PKCB, PKC B, pan-PKC, EC:2.7.11.13

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using PRKCB Monoclonal antibody (68620-1-Ig)

    WB analysis using 68620-1-Ig (same clone as 68620-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68620-1-Ig (PRKCB antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Alpha Tubulin Monoclonal antibody (HRP-66031) as loading control. This data was developed using the same antibody clone with 68620-1-PBS in a different storage buffer formulation.

Product Information

68620-1-PBS targets PRKCB in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.

Tested Reactivity human, mouse, rat, pig, rabbit
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen PRKCB fusion protein Ag33693
Full Name protein kinase C, beta
Calculated Molecular Weight 673 aa, 77 kDa
Observed Molecular Weight 77 kDa
GenBank Accession NumberBC036472
Gene Symbol PRKCB
Gene ID (NCBI) 5579
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. Protein kinase Cs (PKCs) are signaling molecules that play key roles in many cellular processes, including secretion, gene expression, proliferation, and muscle contraction. The PKC family is broadly divided into three subgroups: classical, novel, and atypical PKCs. These subgroups differ in both protein sequences and mechanistic requirements for catalytic activity. PKC beta is one of the PKC family members. PKC beta has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress.