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PR Monoclonal antibody, PBS Only

PR Monoclonal Antibody for IHC, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IHC, ELISA

Conjugate

Unconjugated

CloneNo.

3D1D12

Cat no : 66300-1-PBS

Synonyms

NR3C3, PGR, PR, progesterone receptor

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human breast cancer tissue using PR Monoclonal antibody (66300-1-Ig)

    IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:9900 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using PR Monoclonal antibody (66300-1-Ig)

    IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:9900 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using PR Monoclonal antibody (66300-1-Ig)

    IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:3200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

66300-1-PBS targets PR in IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen PR fusion protein Ag22992
Full Name progesterone receptor
Calculated Molecular Weight 933 aa, 99 kDa
GenBank Accession NumberNM_000926
Gene Symbol Progesterone Receptor
Gene ID (NCBI) 5241
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

Background Information

PGR, also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.