PR Monoclonal antibody, PBS Only

PR Monoclonal Antibody for IHC, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IHC, ELISA

Conjugate

Unconjugated

CloneNo.

3D1D12

Cat no : 66300-1-PBS

Synonyms

NR3C3, PGR, PR, progesterone receptor

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Validation Data Gallery

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  IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:9900 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:9900 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 66300-1-Ig (same clone as 66300-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66300-1-Ig (PR antibody) at dilution of 1:3200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66300-1-PBS in a different storage buffer formulation.

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Product Information

66300-1-PBS targets PR in IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: PR fusion protein Ag22992
• Full Name: progesterone receptor
• Calculated Molecular Weight: 933 aa, 99 kDa
• GenBank Accession Number: NM_000926
• Gene Symbol: Progesterone Receptor
• Gene ID (NCBI): 5241
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS only
• Storage Conditions: Store at -80°C.

Background Information

PGR, also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.