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POLD1 Polyclonal antibody, PBS Only

POLD1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 15646-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

15646-1-PBS targets POLD1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen POLD1 fusion protein Ag8178 Predict reactive species
Full Name polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Calculated Molecular Weight 1107 aa, 124 kDa
Observed Molecular Weight 124 kDa
GenBank Accession NumberBC008800
Gene Symbol POLD1
Gene ID (NCBI) 5424
RRIDAB_2252572
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP28340
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

POLD1, also known as DNA polymerase subunit delta p125, is 1107 amino acid protein, which belongs to the DNA polymerase type-B family. POLD1 colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739). As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. A previous study demonstrated that overexpression of POLD1 is associated with an increased risk of breast cancer. (PMID: 30344713 )

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