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PNMT Recombinant antibody, PBS Only

PNMT Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241111G1

Cat no : 83979-5-PBS

Synonyms

PNMTase, Phenylethanolamine N-methyltransferase, PENT, Noradrenaline N-methyltransferase, EC:2.1.1.28

Validation Data Gallery

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  • Western Blot (WB) analysis of K-562 cells using PNMT Recombinant antibody (83979-5-RR)

    WB analysis of K-562 using 83979-5-RR (same clone as 83979-5-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 83979-5-RR (PNMT antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83979-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83979-5-RR

    Affinity and Kinetic Characterization of 83979-5-RR

    Biolayer interferometry (BLl) kinetic assays of 83979-5-RR against Human PNMT were performed. The affinity constant is 8.83 pM.

Product Information

83979-5-PBS targets PNMT in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PNMT fusion protein Ag4098
Full Name phenylethanolamine N-methyltransferase
Calculated Molecular Weight 282 aa, 31 kDa
GenBank Accession NumberBC037246
Gene Symbol PNMT
Gene ID (NCBI) 5409
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PNMT (Phenylethanolamine N-methyltransferase) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline to epinephrine by transferring a methyl group from S-adenosyl-L-methionine (SAM) to norepinephrine. PNMT is primarily found in the adrenal medulla, where it is responsible for the production of epinephrine. It is also present in certain areas of the brain, such as the amygdala and retina, where it may be involved in various neurophysiological functions (PMID: 17175506). Variations in the PNMT gene have been associated with Alzheimer's disease, hypertension, and other disorders (PMID: 2816488,.11514309).