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PMS2 Monoclonal antibody, PBS Only

PMS2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, rat, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1G4E6

Cat no : 66075-1-PBS

Synonyms

HNPCC4, PMS1 protein homolog 2, PMS2, PMS2CL, PMSL2

Validation Data Gallery

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  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    Vairous cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

Product Information

66075-1-PBS targets PMS2 in WB, Indirect ELISA applications and shows reactivity with human, rat, mouse samples.

Tested Reactivity human, rat, mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen PMS2 fusion protein Ag12661
Full Name PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Calculated Molecular Weight 862 aa, 96 kDa
Observed Molecular Weight 100 kDa
GenBank Accession NumberBC093921
Gene Symbol PMS2
Gene ID (NCBI) 5395
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).