PLS1 Polyclonal antibody, PBS Only

PLS1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 13143-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

13143-1-PBS targets PLS1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PLS1 fusion protein Ag3532 Predict reactive species
Full Name plastin 1 (I isoform)
Calculated Molecular Weight 629 aa, 70 kDa
Observed Molecular Weight70 kDa
GenBank Accession NumberBC031083
Gene Symbol PLS1
Gene ID (NCBI) 5357
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ14651
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PLS1 also known as Fimbrin, Plastin 1, is an actin-binding protein in the absence of calcium. In the inner ear, PLS1 is required for stereocilia formation. PLS1 Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. PLS1 is specifically expressed at high levels in the small intestine, colon, and kidney; relatively expressed at lower levels in the lung and stomach(PMID: 8139549). PLS1 is required for normal hearing in humans and mice. Mutations in PLS1, encoding fimbrin, cause autosomal dominant nonsyndromic hearing loss(NSHL)(PMID: 31397523).

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