Product Information
85167-1-PBS targets PARL in WB, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | PARL fusion protein Ag24789 Predict reactive species |
Full Name | presenilin associated, rhomboid-like |
Calculated Molecular Weight | 42 kDa |
Observed Molecular Weight | 45 kDa |
GenBank Accession Number | BC014058 |
Gene Symbol | PARL |
Gene ID (NCBI) | 55486 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q9H300 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
PARL (Presenilin associated rhomboid like), is a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. PARL has 2 isoforms produced by alternative splicing with the molecular mass of 42 kDa and 37 kDa. PARL regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of PARL may result in the release of a small peptide, P-beta, which may transit to the nucleus. The self-regulated cleavage of PARL at positions 52-53 (α-site) and 77--78 (β-site) produce two cleaved forms of PARL named MAMP and PACT with the molecular mass of 36 kDa and 33 kDa respectively (PMID: 14732705, 28178523).