PARL Recombinant antibody, PBS Only

PARL Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85167-1-PBS
Clone No.242171C12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

PRO2207, Presenilin-associated rhomboid-like protein, mitochondrial, P-beta, Pbeta, EC:3.4.21.105

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

85167-1-PBS targets PARL in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PARL fusion protein Ag24789 Predict reactive species
Full Name presenilin associated, rhomboid-like
Calculated Molecular Weight 42 kDa
Observed Molecular Weight45 kDa
GenBank Accession NumberBC014058
Gene Symbol PARL
Gene ID (NCBI) 55486
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ9H300
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PARL (Presenilin associated rhomboid like), is a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. PARL has 2 isoforms produced by alternative splicing with the molecular mass of 42 kDa and 37 kDa. PARL regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of PARL may result in the release of a small peptide, P-beta, which may transit to the nucleus. The self-regulated cleavage of PARL at positions 52-53 (α-site) and 77--78 (β-site) produce two cleaved forms of PARL named MAMP and PACT with the molecular mass of 36 kDa and 33 kDa respectively (PMID: 14732705, 28178523).

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