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- KD/KO Validated
Nurr1/NR4A2 Monoclonal antibody, PBS Only
Nurr1/NR4A2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1H5B4
Cat no : 66878-1-PBS
Synonyms
Validation Data Gallery
Product Information
66878-1-PBS targets Nurr1/NR4A2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Nurr1/NR4A2 fusion protein Ag1418 |
Full Name | nuclear receptor subfamily 4, group A, member 2 |
Calculated Molecular Weight | 66 kDa |
Observed Molecular Weight | 67 kDa |
GenBank Accession Number | BC009288 |
Gene Symbol | Nurr1 |
Gene ID (NCBI) | 4929 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic mdDA neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].