Product Information
69001-1-PBS targets NeutraKine® IL-6 in IHC, Neutralization, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | human Humankine IL-6 protein HZ-1019 Predict reactive species |
Full Name | interleukin 6 (interferon, beta 2) |
Gene Symbol | IL6 |
Gene ID (NCBI) | 3569 |
ENSEMBL Gene ID | ENSG00000136244 |
RRID | AB_2882919 |
Conjugate | Unconjugated |
Purification Method | Protein G purification |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
This antibody can be used to neutralize the bioactivity of IL-6.