NeutraKine® IL-6 Monoclonal antibody
NeutraKine® IL-6 Monoclonal Antibody for IHC, ELISA, Neutralization
Host / Isotype
Mouse / IgG1
Reactivity
Human and More (2)
Applications
IHC, IF, Neutralization, ELISA
Conjugate
Unconjugated
CloneNo.
4G3E6
Cat no : 69001-1-Ig
Synonyms
Validation Data Gallery
| Neutralization |
Published Applications
| IF | See 1 publications below |
| ELISA | See 1 publications below |
Product Information
69001-1-Ig targets NeutraKine® IL-6 in IHC, IF, Neutralization, ELISA applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Cited Reactivity | human, rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | human Humankine IL-6 protein HZ-1019 |
| Full Name | interleukin 6 (interferon, beta 2) |
| Gene Symbol | IL6 |
| Gene ID (NCBI) | 3569 |
| RRID | AB_2882919 |
| Conjugate | Unconjugated |
| Form | Lyophilized Powder |
| Purification Method | Protein G purification |
| Storage Buffer | Sterile PBS. |
| Endotoxin | <0.1 EU/μg |
| Reconstitution | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Background Information
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
This antibody can be used to neutralize the bioactivity of IL-6.
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for NeutraKine® IL-6 antibody 69001-1-Ig | Download protocol |
| FC protocol for NeutraKine® IL-6 antibody 69001-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Oncogene LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling | ||
Front Immunol Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma | ||
Free Radic Biol Med IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis | ||
Int J Biol Sci The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC. | ||
Biomed Pharmacother Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease. | ||
J Biochem Mol Toxicol Uric acid promotes interleukin-17 expression to cause kidney injury |
