CoraLite® Plus 488-conjugated Neuropeptide Y Polyclonal antibody

Neuropeptide Y Polyclonal Antibody for IF-P

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IF-P

Conjugate

CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-12833

Synonyms

CPON, Neuropeptide tyrosine, neuropeptide Y, NPY, PYY4

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Validation Data Gallery

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  IF Staining of mouse eye using CL488-12833

  Immunofluorescent analysis of (4% PFA) fixed mouse eye tissue using CoraLite® Plus 488 Neuropeptide Y antibody (CL488-12833) at dilution of 1:200.

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Tested Applications

• Positive IF-P detected in: mouse eye tissue

Recommended dilution

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

CL488-12833 targets Neuropeptide Y in IF-P applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Neuropeptide Y fusion protein Ag3568
• Full Name: neuropeptide Y
• Calculated Molecular Weight: 97 aa, 11 kDa
• GenBank Accession Number: BC029497
• Gene Symbol: Neuropeptide Y
• Gene ID (NCBI): 4852
• Conjugate: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 493 nm / 522 nm
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

Neuropeptide Y (NPY) is one of the most abundant peptides in the mammalian central nervous system (CNS). NPY has been linked to several physiological and pathological functions, such as feeding behaviour, memory processing, pain, anxiety, cell proliferation and many other processes in the central and peripheral nervous systems. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. In addition, NPY was suggested as a potential neuroprotective agent in Alzheimer's disease by counteracting the toxic effect of β-amyloid in an in vitro model.