TrkA Recombinant antibody, PBS Only

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  WB analysis of K-562 using 83477-7-RR (same clone as 83477-7-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

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  WB analysis of SH-SY5Y using 83477-7-RR (same clone as 83477-7-PBS)

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83477-7-RR

  Biolayer interferometry (BLl) kinetic assays of 83477-7-RR against Human NTRK1 were performed. The affinity constant is below 1 pM.

TrkA {ptg:Brand} Recombinant Antibody for WB, ELISA

Cat No. 83477-7-PBS

Clone No.240440D12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

NTRK1, Trk A, TRK, p140 TrkA, MTC

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Product Information

83477-7-PBS targets TrkA in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TrkA fusion protein Ag32759
• Full Name: neurotrophic tyrosine kinase, receptor, type 1
• Calculated Molecular Weight: 88 kDa
• Observed Molecular Weight: 140 kDa
• GenBank Accession Number: NM_001007792
• Gene Symbol: NTRK1
• Gene ID (NCBI): 4914
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P04629
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

NTRK1(Neurotrophic tyrosine kinase receptor 1) is located on chromosome 1q23.1 and is responsible for a rare genetic disorder, CIPA (congenital insensitivity to pain with anhidrosis) (PMID: 37907480). As a neurotrophin receptor, NTRK1 is abundantly expressed in human neuronal tissues and plays an integral role in the development and function of the human nervous system (PMID: 27843590). NTRK1 also regulates the survival and proliferation of cholinergic neurons (PMID: 20054812).