NEUROD2 Monoclonal antibody, PBS Only

NEUROD2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C7B3

Cat no : 68284-1-PBS

Synonyms

bHLHa1, NDRF, NeuroD related factor, NEUROD2, neurogenic differentiation 2

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Validation Data Gallery

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  WB analysis using 68284-1-Ig (same clone as 68284-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68284-1-Ig (NEUROD2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 68284-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse cerebellum using 68284-1-Ig (same clone as 68284-1-PBS)

  mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 68284-1-Ig (NEUROD2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68284-1-PBS in a different storage buffer formulation.

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Product Information

68284-1-PBS targets NEUROD2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, pig samples.

• Tested Reactivity: Human, mouse, pig
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: NEUROD2 fusion protein Ag26068
• Full Name: neurogenic differentiation 2
• Calculated Molecular Weight: 41 kDa
• Observed Molecular Weight: 41-50 kDa
• GenBank Accession Number: BC022481
• Gene Symbol: NEUROD2
• Gene ID (NCBI): 4761
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

NEUROD2 (Neurogenic differentiation factor 2), is transcriptional regulator that regulates early neuronal differentiation during development (PMID: 7754368). NeuroD2 is expressed in the postnatal cortex and mediate the activity-dependent refinement of thalamocortical axon terminals (PMID: 17453014). NeuroD2 is mainly involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Mutantions in NEUROD2 can cause neurodevelopmental disorders including intellectual disability and autism spectrum disorders (PMID: 34188164).