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MTMR4 Recombinant antibody, PBS Only

MTMR4 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241304E11

Cat no : 84328-1-PBS

Synonyms

KIAA0647, FYVE-DSP2, FYVE DSP2, FYVE domain-containing dual specificity protein phosphatase 2, EC:3.1.3.48

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using MTMR4 Recombinant antibody (84328-1-RR)

    IF Staining of HepG2 using 84328-1-RR (same clone as 84328-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using MTMR4 antibody (84328-1-RR, Clone: 241304E11 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84328-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84328-1-RR

    Affinity and Kinetic Characterization of 84328-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84328-1-RR against Human MTMR4 were performed. The affinity constant is 2.06 nM.

Product Information

The immunogen of 84328-1-PBS is MTMR4 Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen MTMR4 fusion protein Ag4310
Full Name myotubularin related protein 4
Calculated Molecular Weight 1195 aa, 133 kDa
Observed Molecular Weight 133 kDa
GenBank Accession NumberBC035609
Gene Symbol MTMR4
Gene ID (NCBI) 9110
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Myotubularin-related protein-4 (MTMR4), also named FYVE-DSP2, is a member of the myotubularin family of phosphoinositide phosphatases that selectively degrade the 3-position phosphate from the inositol ring of PtdIns(3)P and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PMID: 31543504). MTMR4 knockdown markedly suppressed the motility, fusion, and fission of PI(3)P- enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes, and enlargement of PI(3)P- enriched early and late endosomes(PMID: 29962048).